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FR 180204
CAS No. 865362-74-9
FR 180204 ( FR180204 | FR-180204 )
产品货号. M16283 CAS No. 865362-74-9
FR 180204 是一种有效的、选择性的、ATP 竞争性 ERK 抑制剂，对于 ERK1 和 ERK2 的 Ki 值分别为 0.31 和 0.14 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥405 | 有现货 |
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| 5MG | ￥632 | 有现货 |
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| 10MG | ￥1134 | 有现货 |
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| 25MG | ￥1887 | 有现货 |
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| 50MG | ￥2827 | 有现货 |
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| 100MG | ￥4236 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称FR 180204
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述FR 180204 是一种有效的、选择性的、ATP 竞争性 ERK 抑制剂，对于 ERK1 和 ERK2 的 Ki 值分别为 0.31 和 0.14 uM。
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产品描述FR 180204 is a potent, selective, ATP-competitive ERK inhibitor with Ki of 0.31 and 0.14 uM for ERK1 and ERK2, respectively; inhibits TGFβ-induced luciferase-expression in mink lung epithelial Mv1Lu cells, decreases plasma anti-CII antibody levels and attenuates delayed-type hypersensitivity in CII-immunized DBA/1 mice, also inhibits in vitro CII-induced proliferation of lymph node cells prepared from CII-immunized mice; enhances apoptotic and anti-proliferative effects of Akt inhibitor API-1 in human DLD-1 and LoVo colorectal cancer cells.
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体外实验In AP-1-transfected cells, FR180204 dose-dependently inhibits AP-1 transactivation with IC50 of 3.1 μM.?FR 180204 inhibits spontaneous mesothelioma cell growth.
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体内实验FR180204 (100 mg/kg, i.p., b.i.d.) significantly decreases the severity of symptoms and body weight loss in collagen-induced arthritis mice.In a mouse model of dengue virus (DENV) infection, FR180204 limits hepatocyte apoptosis, reduces DENV-induced liver injury, and improves clinical parameters.
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同义词FR180204 | FR-180204
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通路MAPK/ERK Signaling
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靶点ERK
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受体ERK1|ERK2
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研究领域Cancer
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适应症——
化学信息
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CAS Number865362-74-9
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分子量327.3427
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分子式C18H13N7
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 50 mg/mL
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SMILESNC1=NNC2=NN=C(C3=C4C=CC=CN4N=C3C5=CC=CC=C5)C=C21
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化学全称1H-Pyrazolo[3,4-c]pyridazin-3-amine, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ohori M, et al. Biochem Biophys Res Commun. 2005 Oct 14;336(1):357-63.
2. Ohori M, et al. Naunyn Schmiedebergs Arch Pharmacol.
3. Chen-Roetling J, et al. Neuropharmacology. 2009 Apr;56(5):922-8.
4. Saglam AS, et al. Oncol Lett. 2016 Oct;12(4):2463-2474.
